Thomas Langmann Selected Research

Lasers (Laser)

12/2020	IFN-β signaling dampens microglia reactivity but does not prevent from light-induced retinal degeneration.
4/2020	A Circulating MicroRNA Profile in a Laser-Induced Mouse Model of Choroidal Neovascularization.
2/2019	Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina.
1/2019	Testing for Known Retinal Degeneration Mutants in Mouse Strains.
6/2017	Comprehensive analysis of mouse retinal mononuclear phagocytes.
1/2017	Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina.
1/2016	Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization.

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Thomas Langmann Research Topics

Disease

17	Retinal Degeneration 01/2023 - 09/2009
13	Macular Degeneration (Age-Related Maculopathy) 01/2023 - 02/2008
7	Inflammation (Inflammations) 11/2021 - 01/2014
7	Choroidal Neovascularization 01/2021 - 01/2016
6	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2022 - 01/2010
5	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2023 - 09/2010
5	Neoplasms (Cancer) 08/2009 - 03/2004
5	Crohn Disease (Crohn's Disease) 07/2009 - 07/2004
5	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 07/2009 - 07/2004
4	Retinoschisis (Retinoschisis, Juvenile) 04/2011 - 02/2007
4	Atherosclerosis 02/2010 - 04/2004
4	Ulcerative Colitis 07/2009 - 03/2006
3	Disease Progression 11/2021 - 01/2018
3	Pathologic Neovascularization 11/2021 - 01/2016
3	Retinal Diseases 01/2021 - 09/2010
3	Gliosis 01/2020 - 01/2013
3	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 01/2018 - 01/2013
3	Cardiovascular Diseases (Cardiovascular Disease) 02/2006 - 08/2004
2	Neuroinflammatory Diseases 09/2022 - 01/2014
2	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2021 - 10/2018
2	Retinopathy of Prematurity (Retrolental Fibroplasia) 01/2021 - 01/2016
2	Infections 11/2015 - 01/2009
2	Hippocampal Sclerosis 01/2011 - 03/2006
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2009 - 04/2004
2	Melanoma (Melanoma, Malignant) 10/2007 - 01/2005
2	Leukemia 05/2005 - 01/2005
1	Pathologic Processes 01/2021
1	Multiple Sclerosis 12/2020
1	Blindness (Hysterical Blindness) 11/2020
1	Vision Disorders (Hemeralopia) 11/2020
1	Eye Diseases (Eye Disease) 01/2020
1	Hyperglycemia 01/2020
1	Retinal Dystrophies 10/2018
1	Cysts 01/2018
1	Nervous System Diseases (Neurological Disorders) 01/2018
1	Macular Edema 01/2018
1	Anterior Uveitis 01/2018
1	Protein Deficiency 01/2017
1	Niemann-Pick Diseases (Niemann Pick Disease) 08/2015
1	Glioma (Gliomas) 01/2015
1	Drug Resistant Epilepsy 01/2011
1	Temporal Lobe Epilepsy 01/2011

Drug/Important Bio-Agent (IBA)

27	Retinaldehyde (Retinal)IBA 01/2023 - 02/2007
16	Proteins (Proteins, Gene)FDA Link 09/2022 - 04/2004
9	ATP-Binding Cassette Transporters (ABC Transporters)IBA 12/2017 - 08/2002
7	LigandsIBA 11/2021 - 01/2014
6	Messenger RNA (mRNA)IBA 01/2009 - 03/2004
5	LipidsIBA 01/2017 - 04/2004
4	CytokinesIBA 11/2021 - 03/2006
4	CholesterolIBA 02/2010 - 08/2002
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 01/2019
3	Minocycline (Cyclops)FDA LinkGeneric 01/2018 - 11/2015
3	HDL LipoproteinsIBA 12/2017 - 09/2005
3	DNA (Deoxyribonucleic Acid)IBA 09/2010 - 12/2006
3	beta Carotene (Betacarotene)FDA Link 05/2005 - 01/2005
2	Interferon-betaIBA 12/2020 - 01/2016
2	Neuroprotective AgentsIBA 11/2020 - 01/2018
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2014
2	Complement System Proteins (Complement)IBA 05/2017 - 01/2017
2	polysialic acidIBA 05/2017 - 01/2017
2	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 11/2015 - 11/2015
2	Docosahexaenoic AcidsIBA 01/2013 - 09/2009
2	CurcuminIBA 01/2013 - 09/2011
2	Adenosine Triphosphate (ATP)IBA 08/2009 - 08/2004
2	Bile Acids and Salts (Bile Acids)IBA 07/2009 - 02/2006
2	Multidrug Resistance-Associated ProteinsIBA 12/2008 - 03/2006
2	SterolsIBA 02/2006 - 08/2002
2	EphrinsIBA 07/2005 - 03/2004
1	pexidartinibIBA 01/2023
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2023
1	Macrophage Colony-Stimulating FactorIBA 01/2023
1	galactose-binding proteinIBA 09/2022
1	Galectin 3 (LGALS3)IBA 09/2022
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2021
1	Vascular Endothelial Growth Factor BIBA 01/2021
1	Circulating MicroRNAIBA 04/2020
1	AntioxidantsIBA 01/2020
1	ChemokinesIBA 01/2020
1	Prostaglandins FIBA 02/2019
1	High-Temperature Requirement A Serine Peptidase 1IBA 01/2019
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2018
1	Nerve Growth Factors (Neurotrophins)IBA 01/2018
1	HLA-B27 Antigen (HLA B27 Antigen)IBA 01/2018
1	Rhodopsin (Visual Purple)IBA 02/2016
1	Oxygen (Dioxygen)IBA 01/2016
1	InterferonsIBA 01/2016
1	N- benzyl- N- ethyl- 2- (7,8- dihydro- 7- methyl- 8- oxo- 2- phenyl- 9H- purin- 9- yl)acetamideIBA 11/2015
1	Toll-Like Receptors (Toll-Like Receptor)IBA 11/2015
1	AcidsIBA 08/2015
1	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 08/2015
1	neodymium pyrocatechin disulfonate (NPD)IBA 08/2015
1	whey acidic proteinsIBA 04/2015
1	Complement Factor H (Factor H)IBA 03/2014
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2014
1	palmitoyl-protein thioesteraseIBA 04/2013
1	Adenosine Triphosphatases (ATPase)IBA 03/2011
1	Nonsense Codon (Nonsense Mutation)IBA 09/2010

Therapy/Procedure

9	Therapeutics 11/2020 - 02/2006
7	Lasers (Laser) 12/2020 - 01/2016
5	Immunomodulation 09/2022 - 05/2017